Publications

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2017

Ramos CL, Gomes FM, Girard-Dias W, Almeida FP, Albuquerque PC, Kretschmer M, Kronstad JW, Frases S, de Souza W, Rodrigues ML, Miranda K. 2017. Phosphorus-rich structures and capsular architecture in Cryptococcus neoformans. Future Microbiol. 12: 227-38. Epub 2017 Feb 20.

Bairwa G, Hee Jung W, Kronstad JW. 2017. Iron acquisition in fungal pathogens of humans. Metallomics. 9: 215-27.

Kwon-Chung KJ, Bennett JE, Wickes BL, Meyer W, Cuomo CA, Wollenburg KR, Bicanic TA, Castañeda E, Chang YC, Chen J, Cogliati M, Dromer F, Ellis D, Filler SG, Fisher MC, Harrison TS, Holland SM, Kohno S, Kronstad JW, Lazera M, Levitz SM, Lionakis MS, May RC, Ngamskulrongroj P, Pappas PG, Perfect JR, Rickerts V, Sorrell TC, Walsh TJ, Williamson PR, Xu J, Zelazny AM, Casadevall A. 2017. The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis. mSphere. 2: e00357-16.

Hu G, Caza M, Bakkeren E, Kretschmer M, Bairwa G, Reiner E, Kronstad J. 2017. A P4-ATPase subunit of the Cdc50 family plays a role in iron acquisition and virulence in Cryptococcus neoformans. Cell Microbiol. 19. Epub 2017 Jan 23. (Editor’s Choice)

Santana AG, Tysoe C, Hu G, Kronstad J, Goddard-Borger ED, Withers SG. 2017. Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans. Chembiochem. 18: 284-90. Epub 2017 Jan 3.

Mayer FL, Kronstad JW. 2017. Discovery of a Novel Antifungal Agent in the Pathogen Box. mSphere. 2: e00120-17.

Lambie SC, Kretschmer M, Croll D, Haslam TM, Kunst L, Klose J, Kronstad JW. 2017. The putative phospholipase Lip2 counteracts oxidative damage and influences the virulence of Ustilago maydis. Mol Plant Pathol. 18: 210-21. Epub 2016 Apr 21.

2016

Do E, Park M, Hu G, Caza M, Kronstad JW, Jung WH. 2016. The lysine biosynthetic enzyme Lys4 influences iron metabolism, mitochondrial function and virulence in Cryptococcus neoformans.
Biochem Biophys Res Commun. 477: 706-11. Epub 2016 Jun 25.

Kretschmer M, Croll D, Kronstad JW. 2016. Maize susceptibility to Ustilago maydis is influenced by genetic and chemical perturbation of carbohydrate allocation. Mol Plant Pathol. Epub 2016 Aug 26.

Kretschmer M, Croll D, Kronstad JW. 2016. Chloroplast-associated metabolic functions influence the susceptibility of maize to Ustilago maydis. Mol Plant Pathol. Epub 2016 Aug 26.

McCotter SW, Horianopoulos LC, Kronstad JW. 2016. Regulation of the fungal secretome. Curr Genet. 62: 533-45. Epub 2016 Feb 15. Review.

Do E, Hu G, Caza M, Kronstad JW, Jung WH. 2016. The ZIP family zinc transporters support the virulence of Cryptococcus neoformans. Med Mycol. 54: 605-15. Epub 2016 Apr 26.

Ding H, Mayer FL, Sánchez-León E, de S Araújo GR, Frases S, Kronstad JW. 2016. Networks of fibers and factors: regulation of capsule formation in Cryptococcus neoformans. F1000Res. 5: F1000 Faculty Rev-1786.

Caza M, Hu G, Price M, Perfect JR, Kronstad JW. 2016. The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans. mSphere. 1: e00080-15.

Geddes JM, Caza M, Croll D, Stoynov N, Foster LJ, Kronstad JW. 2016. Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation. MBio. 7: e01862-15.

2015

Choi J, Jung WH, Kronstad JW. 2015. The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis. J Microbiol. 53: 579-87.

Geddes JM, Croll D, Caza M, Stoynov N, Foster LJ, Kronstad JW. 2015. Secretome profiling of  Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A. BMC Microbiol. 15: 206-.

Do E, Hu G, Caza M, Oliveira D, Kronstad JW, Jung WH. 2015. Leu1 plays a role in iron metabolism and is required for virulence in Cryptococcus neoformans. Fungal Genet Biol. 75: 11-19.

Hu G, Caza M, Cadieux B, Bakkeren E, Do E, Jung WH, Kronstad JW. 2015. The ESCRT machinery influences haem uptake and capsule elaboration in Cryptococcus neoformans. Mol Microbiol. 96: 973-92.

2014

Billmyre, R.B., Croll, D., Li, W., Mieczkowski, P., Carter, D.A., Cuomo, C.A., Kronstad J.W. and Heitman, J. 2014. Highly recombinant VGII C. gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution. mBio 5: e01494-14.

Kretschmer M, Reiner E, Hu G, Tam N, Oliveira DL, Caza M, Yeon JH, Kim J, Kastrup CJ, Jung WH, Kronstad JW. 2014. Defects in phosphate acquisition and storage influence the virulence of Cryptococcus neoformans. Infect. & Immun. 82: 2697-2712. Selected as a “Spotlight” article of significant interest by the editors.

Rizzo, J., Oliveira, D., Joffe, L., Hu, G., Gazos-Lopes, F., Fonseca, F.L., Almeida, I., Frases, S., Kronstad, J. and Rodrigues, M. 2014. Role of the Apt1 flippase in polysaccharide secretion by Cryptococcus neoformans. Eukaryotic Cell 13: 715-26.

Saikia, S. Oliveira, D., Hu, G. and Kronstad, J. 2014. Role of ferric reductases in iron acquisition and virulence in the fungal pathogen Cryptococcus neoformans. Infect. Immun. 82: 839-50. Selected as a “Spotlight” article of significant interest by the editors.

Janbon G, Ormerod KL, Paulet D, Byrnes III EJ, Yadav V, Chatterjee G, Mullapudi N, Hon C-C, Billmyre RB, Brunel F, Bahn Y-S, Chen W, Chen Y, Chow EWL, Coppée J-Y, Floyd-Averette A, Gaillardin C, Gerik KJ, Goldberg J, Gonzalez-Hilarion S, Gujja S, Hamlin JL, Hsueh Y-P, Ianiri G, Jones J, Kodira CD, Kozubowski L, Lam W, Marra M, Mesner LD, Mieczkowski PA, Moyrand F, Nielsen K, Proux C, Rossignol T, Schein JE, Sun S, Wollschlaeger C, Wood IA, Zeng Q, Neuvéglise C, Newlon CS, Perfect JR, Lodge JK, Idnurm A, Stajich JE, Kronstad JW, Sanyal K, Heitman J, Fraser JA, Cuomo CA and Dietrich FS. 2014. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet. 10(4):e1004261. UBC/GSC team underlined.

2013

Hu G, Caza M, Cadieux B, Chan V, Liu V, Kronstad JW. 2013. Cryptococcus neoformans requires the ESCRT protein Vps23 for iron acquisition from heme, for capsule formation, and for virulence. Infection and Immunity 81: 292-302.

Cadieux B, Lian T, Hu G, Wang J, Biondo C, Teti G, Liu V, Murphy ME, Creagh AL, Kronstad JW. 2013.
The mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans. J Infect Dis. 207: 1339-47.

Leongson, K., Cusineau-Cote, V., Goupil, M., Aumont, F., Senechal, S., Gaboury, L., Jolicoeur, P., Kronstad, J.W., de Repentingny, L. 2013. Altered Immune Response Differentially Enhances Susceptibility to Cryptococcus neoformans and Cryptococcus gattii infection in Mice Expressing the HIV-1 Transgene.  Infect. Immun. 81: 1100-13.

2012

Kronstad J, Saikia S, Nielson ED, Kretschmer M, Jung W, Hu G, Geddes JM, Griffiths EJ, Choi J, Cadieux B, Caza M, Attarian R. 2012. Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence. Eukaryot Cell. 11: 109-18.

Griffiths EJ, Kretschmer M, Kronstad JW. 2012. Aimless mutants of Cryptococcus neoformans: failure to disseminate. Fungal Biol Rev. 26: 61-72.

Griffiths EJ, Hu G, Fries B, Caza M, Wang J, Gsponer J, Gates-Hollingsworth MA, Kozel TR, De Repentigny L, Kronstad JW. 2012. A defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans. Mol Microbiol. 86: 1404-23.

Choi J, Vogl AW, Kronstad JW. 2012. Regulated expression of cyclic AMP-dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in Cryptococcus neoformans. Mol Microbiol. 85: 700-15.

Kretschmer M, Wang J, Kronstad JW. 2012. Peroxisomal and mitochondrial β-oxidation pathways influence the virulence of the pathogenic fungus Cryptococcus neoformans.
Eukaryot Cell. 11: 1042-54.

Kretschmer M, Klose J, Kronstad JW. 2012. Defects in mitochondrial and peroxisomal β-oxidation influence virulence in the maize pathogen Ustilago maydis. Eukaryot Cell. 11: 1055-66.

2011

Kronstad JW, Hu G, Choi J. 2011. The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans. Mycobiology. 39: 143-50.

Hu G, Wang J, Choi J, Jung WH, Liu I, Litvintseva AP, Bicanic T, Aurora R, Mitchell TG, Perfect JR, Kronstad JW. 2011. Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients. BMC Genomics. 12: 526.

Jung WH, Kronstad JW. 2011. Iron influences the abundance of the iron regulatory protein Cir1 in the fungal pathogen Cryptococcus neoformans. FEBS Lett. 585: 3342-7.

Kronstad JW, Attarian R, Cadieux B, Choi J, D’Souza CA, Griffiths EJ, Geddes JM, Hu G, Jung WH, Kretschmer M, Saikia S, Wang J. 2011. Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box. Nat Rev Microbiol. 9: 193-203.

Jung WH, Kronstad JW. 2011. The iron-responsive, GATA-type transcription factor Cir1 influences mating in Cryptococcus neoformans. Mol Cells. 31: 73-7.

2010

Jung WH, Saikia S, Hu G, Wang J, Fung CK, D’Souza C, White R, Kronstad JW. 2010. HapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans.
PLoS Pathog. 6: e1001209.

Hu G, Kronstad JW. 2010. A putative P-type ATPase, Apt1, is involved in stress tolerance and virulence in Cryptococcus neoformans. Eukaryot Cell. 9: 74-83. Epub 2009 Nov 30.

Xue, C., Liu, T., Chen, L., Li, W. Liu, I., Kronstad, J.W., Seyfang, A., and Heitman, J. 2010. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence.
mBio. 1: e00084-1.

2009

Jung WH, Hu G, Kuo W, Kronstad JW. 2009. Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans. Eukaryot Cell. 8: 1511-20. Epub 2009 Aug 21.

Cheng PY, Sham A, Kronstad JW. 2009. Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus neoformans. Infect Immun. 77: 4284-94. Epub 2009 Jul 27.

2008

Hu G, Cheng PY, Sham A, Perfect JR, Kronstad JW. 2008. Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. Mol Microbiol. 69: 1456-75. Epub 2008 Jul 30.

Kronstad JW. 2008. Mining the genome of the biotrophic fungal pathogen Ustilago maydis. Fungal Genet Biol. 45 Suppl 1: S1-2. Epub 2008 May 20.

Bartlett KH, Kidd SE, Kronstad JW. 2008. The Emergence of Cryptococcus gattii in British Columbia and the Pacific Northwest. Curr Infect Dis Rep. 10: 58-65.

Jung WH, Sham A, Lian T, Singh A, Kosman DJ, Kronstad JW. 2008. Iron source preference and regulation of iron uptake in Cryptococcus neoformans. PLoS Pathog. 4: e45.

Jung WH, Kronstad JW. 2008. Iron and fungal pathogenesis: a case study with Cryptococcus neoformans. Cell Microbiol. 10: 277-84. Epub 2007 Nov 27. Review.

Hu G, Liu I, Sham A, Stajich JE, Dietrich FS, Kronstad JW. 2008. Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans. Genome Biol. 9: R41. Epub 2008 Feb 22.

2007

Kidd SE, Bach PJ, Hingston AO, Mak S, Chow Y, MacDougall L, Kronstad JW, Bartlett KH. 2007. Cryptococcus gattii dispersal mechanisms, British Columbia, Canada. Emerg Infect Dis. 13: 51-7.

MacDougall L, Kidd SE, Galanis E, Mak S, Leslie MJ, Cieslak PR, Kronstad JW, Morshed MG, Bartlett KH. 2007. Spread of Cryptococcus gattii in British Columbia, Canada, and detection in the Pacific Northwest, USA. Emerg Infect Dis. 13: 42-50.

Hu G, Steen BR, Lian T, Sham AP, Tam N, Tangen KL, Kronstad JW. 2007. Transcriptional regulation by protein kinase A in Cryptococcus neoformans. PLoS Pathog. 3: e42.

Nazi I, Scott A, Sham A, Rossi L, Williamson PR, Kronstad JW, Wright GD. 2007. Role of homoserine transacetylase as a new target for antifungal agents. Antimicrob Agents Chemother. 51: 1731-6. Epub 2007 Mar 12.

Kidd SE, Chow Y, Mak S, Bach PJ, Chen H, Hingston AO, Kronstad JW, Bartlett KH. 2007. Characterization of environmental sources of the human and animal pathogen Cryptococcus gattii in British Columbia, Canada, and the Pacific Northwest of the United States. Appl Environ Microbiol. 73: 1433-43. Epub 2006 Dec 28.

Tangen KL, Jung WH, Sham AP, Lian T, Kronstad JW. 2007. The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans. Microbiology. 153: 29-41.

2006

Jung WH, Sham A, White R, Kronstad JW. 2006. Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans. PLoS Biol. 4: e410.

Kämper J, Kahmann R, Bölker M, Ma LJ, Brefort T, Saville BJ, Banuett F, Kronstad JW, Gold SE, Müller O, Perlin MH, Wösten HA, de Vries R, Ruiz-Herrera J, Reynaga-Peña CG, Snetselaar K, McCann M, Pérez-Martín J, Feldbrügge M, Basse CW, Steinberg G, Ibeas JI, Holloman W, Guzman P, Farman M, Stajich JE, Sentandreu R, González-Prieto JM, Kennell JC, Molina L, Schirawski J, Mendoza-Mendoza A, Greilinger D, Münch K, Rössel N, Scherer M, Vranes M, Ladendorf O, Vincon V, Fuchs U, Sandrock B, Meng S, Ho EC, Cahill MJ, Boyce KJ, Klose J, Klosterman SJ, Deelstra HJ, Ortiz-Castellanos L, Li W, Sanchez-Alonso P, Schreier PH, Häuser-Hahn I, Vaupel M, Koopmann E, Friedrich G, Voss H, Schlüter T, Margolis J, Platt D, Swimmer C, Gnirke A, Chen F, Vysotskaia V, Mannhaupt G, Güldener U, Münsterkötter M, Haase D, Oesterheld M, Mewes HW, Mauceli EW, DeCaprio D, Wade CM, Butler J, Young S, Jaffe DB, Calvo S, Nusbaum C, Galagan J, Birren BW. 2006. Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature. 444: 97-101.

Klose J, Kronstad JW. 2006. The multifunctional beta-oxidation enzyme is required for full symptom development by the biotrophic maize pathogen Ustilago maydis. Eukaryot Cell. 5: 2047-61. Epub 2006 Sep 22.

Kronstad JW. 2006. Serial analysis of gene expression in eukaryotic pathogens. Infect Disord Drug Targets. 6: 281-97. Review.

Boyce KJ, Kretschmer M, Kronstad JW. 2006. The vtc4 gene influences polyphosphate storage, morphogenesis, and virulence in the maize pathogen Ustilago maydis. Eukaryot Cell. 5: 1399-409.

Bakkeren G, Jiang G, Warren RL, Butterfield Y, Shin H, Chiu R, Linning R, Schein J, Lee N, Hu G, Kupfer DM, Tang Y, Roe BA, Jones S, Marra M, Kronstad JW. 2006. Mating factor linkage and genome evolution in basidiomycetous pathogens of cereals. Fungal Genet Biol. 43: 655-66. Epub 2006 Jun 21.

Warren RL, Varabei D, Platt D, Huang X, Messina D, Yang SP, Kronstad JW, Krzywinski M, Warren WC, Wallis JW, Hillier LW, Chinwalla AT, Schein JE, Siddiqui AS, Marra MA, Wilson RK, Jones SJ. 2006. Physical map-assisted whole-genome shotgun sequence assemblies. Genome Res. 16: 768-75.

Hu G, Kronstad JW. 2006. Gene disruption in Cryptococcus neoformans and Cryptococcus gattii by in vitro transposition. Curr Genet. 49: 341-50. Epub 2006 Jan 6.

2005

Boyce KJ, Chang H, D’Souza CA, Kronstad JW. 2005. An Ustilago maydis septin is required for filamentous growth in culture and for full symptom development on maize. Eukaryot Cell. 4: 2044-56.

Larraya LM, Boyce KJ, So A, Steen BR, Jones S, Marra M, Kronstad JW. 2005. Serial analysis of gene expression reveals conserved links between protein kinase A, ribosome biogenesis, and phosphate metabolism in Ustilago maydis. Eukaryot Cell. 4: 2029-43.

Kidd SE, Guo H, Bartlett KH, Xu J, Kronstad JW. 2005. Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areas. Eukaryot Cell. 4: 1629-38.

Lian T, Simmer MI, D’Souza CA, Steen BR, Zuyderduyn SD, Jones SJ, Marra MA, Kronstad JW. 2005. Iron-regulated transcription and capsule formation in the fungal pathogen Cryptococcus neoformans. Mol Microbiol. 55: 1452-72.

Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, Donlin MJ, D’Souza CA, Fox DS, Grinberg V, Fu J, Fukushima M, Haas BJ, Huang JC, Janbon G, Jones SJ, Koo HL, Krzywinski MI, Kwon-Chung JK, Lengeler KB, Maiti R, Marra MA, Marra RE, Mathewson CA, Mitchell TG, Pertea M, Riggs FR, Salzberg SL, Schein JE, Shvartsbeyn A, Shin H, Shumway M, Specht CA, Suh BB, Tenney A, Utterback TR, Wickes BL, Wortman JR, Wye NH, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, Hyman RW. 2005. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 307: 1321-4. Epub 2005 Jan 13.

2004

Klose J, de Sá MM, Kronstad JW. 2004. Lipid-induced filamentous growth in Ustilago maydis. Mol Microbiol. 52: 823-35.

Linning R, Lin D, Lee N, Abdennadher M, Gaudet D, Thomas P, Mills D, Kronstad JW, Bakkeren G. 2004. Marker-based cloning of the region containing the UhAvr1 avirulence gene from the basidiomycete barley pathogen Ustilago hordei. Genetics. 166: 99-111.

2003

Steen BR, Zuyderduyn S, Toffaletti DL, Marra M, Jones SJ, Perfect JR, Kronstad J. 2003 Cryptococcus neoformans gene expression during experimental cryptococcal meningitis. Eukaryot Cell. 2: 1336-49.

Kronstad JW. 2003. Castles and cuitlacoche: the first international Ustilago conference. Fungal Genet Biol. 38: 265-71. Review.

Lee N, D’Souza CA, Kronstad JW. 2003. Of smuts, blasts, mildews, and blights: cAMP signaling in phytopathogenic fungi. Annu Rev Phytopathol. 41: 399-427. Epub 2003 Mar 10. Review.

2002

Lee N, Kronstad JW. 2002. ras2 Controls morphogenesis, pheromone response, and pathogenicity in the fungal pathogen Ustilago maydis. Eukaryot Cell. 1: 954-66.

Alspaugh JA, Pukkila-Worley R, Harashima T, Cavallo LM, Funnell D, Cox GM, Perfect JR, Kronstad JW, Heitman J. 2002. Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryot Cell. 1: 75-84.

Abramovitch RB, Yang G, Kronstad JW. 2002. The ukb1 gene encodes a putative protein kinase required for bud site selection and pathogenicity in Ustilago maydis. Fungal Genet Biol. 37: 98-108.

Schein JE, Tangen KL, Chiu R, Shin H, Lengeler KB, MacDonald WK, Bosdet I, Heitman J, Jones SJ, Marra MA, Kronstad JW. 2002. Physical maps for genome analysis of serotype A and D strains of the fungal pathogen Cryptococcus neoformans. Genome Res. 12: 1445-53.

Steen BR, Lian T, Zuyderduyn S, MacDonald WK, Marra M, Jones SJ, Kronstad JW. 2002. Temperature-regulated transcription in the pathogenic fungus Cryptococcus neoformans. Genome Res. 12: 1386-400.